Diisopropyl phosphate


In enzymology, a diisopropyl-fluorophosphatase is an enzyme that catalyzes the chemical reaction

diisopropyl fluorophosphate + H2O rightleftharpoons diisopropyl phosphate + fluoride

Thus, the two substrates of this enzyme are diisopropyl fluorophosphate and H2O, whereas its two products are diisopropyl phosphate and fluoride.

This enzyme belongs to the family of hydrolases, specifically those acting on ester bonds phosphoric-triester hydrolases. The systematic name of this enzyme class is diisopropyl-fluorophosphate fluorohydrolase. Other names in common use include DFPase, tabunase, somanase, organophosphorus acid anhydrolase, organophosphate acid anhydrase, OPA anhydrase, diisopropylphosphofluoridase, dialkylfluorophosphatase, diisopropyl phosphorofluoridate hydrolase, isopropylphosphorofluoridase, and diisopropylfluorophosphonate dehalogenase. It employs one cofactor, divalent cation. At least one compound, Chelating agent is known to inhibit this enzyme.

Structural studies

As of late 2007, 16 structures have been solved for this class of enzymes, with PDB accession codes , , , , , , , , , , , , , , , and .


  • Augustinsson K-B and Heimburger G "Enzymatic hydrolysis of organophosphorus compounds. I. Occurrence of enzymes hydrolysing dimethyl-amido-ethoxy-phosphoryl cyanide (Tabun)". Acta Chem. Scand. 8 753–761.
  • Augustinsson K-B and Heimburger G "Enzymatic hydrolysis of organophosphorus compounds. II. Analysis of reaction products in experiments with Tabun and some properties of blood plasma tabunase". Acta Chem. Scand. 8 762–767.
  • Augustinsson K-B and Heimburger G "Enzymatic hydrolysis of organophosphorus compounds. IV. Specificity studies". Acta Chem. Scand. 8 1533–1541.
  • COHEN JA, WARRINGA MG "Purification and properties of dialkylfluorophosphatase". Biochim. Biophys. Acta. 26 29–39.
  • Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 4, Academic Press, New York, 1960, p. 541-550.
  • UK, 1989

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes

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