In October of that same year, the band entered the studio for the second time to record the MCD, Lost Euphoria, which contained four songs. Lost Euphoria was released in January 2000 through Skull Crusher Records. After the release, Detonation played ten shows as the supporting act for the Dutch metal band Orphanage.
In March 2001, Detonation entered the studio again to record three new songs that were to be released as a promo CD meant primarily for labels and venues. After playing numerous shows, which also included Detonation's first show outside Holland (Open Hell Fest in the Czech Republic), the band decided to record their debut studio album, An Epic Defiance. The album was recorded within two weeks at Studio Excess and contained twelve songs. The artwork was done by Niklas Sundin (Dark Tranquillity) for Cabin Fever Media.
On October 19, 2002, An Epic Defiance was self-released and sent to record labels. The album caught the attention of the French record label, Osmose Productions and Detonation signed a recording contract for three albums. An Epic Defiance was officially re-released worldwide on CD and limited LP on June 19, 2003. In July 2003, Detonation successfully completed their first foreign tour, playing three shows throughout England. After promoting the album in the Netherlands, the band again headed to the UK to successfully complete a ten-day tour throughout the country.
In February 2004, Detonation took part in a thirteen-day European tour as a support act for Dimension Zero along with Immemorial. In August 2004, the band was forced to recruit a session drummer due to an arm injury of Thomas. Fedor Tieleman of the Dutch band M-90’s was recruited as the session member.
In December 2004, Detonation entered Excess Studios once again to record their second studio album, Portals to Uphobia. Due to numerous problems the official release date was delayed until September 12, 2005. Detonation then toured with Decapitated, Gorerotted, and Dam. Over 30 shows were scheduled throughout Europe, but due to a breakdown of the rented tour bus, Detonation had to cancel several shows. The band eventually managed to complete about half of the shows with their own transportation.
In January 2007, Detonation recorded their third studio album, Emission Phase, which was released at the end of April 2007. The artwork was made by Eliran Kantor and the production was taken care of by Bouke Visser and Jochem Jacobs from Split Second Sound. The release was promoted by an eight-day tour throughout the UK and several individual gigs (festival) in the Netherlands.
On March 17, 2008, the band announced their first ever line-up change. Koen Romeijn who had been playing Rhythmic guitar/Vocals since 1997 decided to lay down his guitar and focus on the vocals. The person they chose to replace him was Danny Tunker from Fuelblooded and The Saturnine.
On May 3, 2008, Detonation announced that their drummer Thomas Kalksma (who was also a forming member of the band) had decided to leave the band for differences of opinion about the future of Detonation. He left in good terms and mentioned that he would continue his drummer career.
Detonation is now looking for a drummer to work on their fourth studio album. Their next gig with the new line-up (Danny on the guitar and an unknown drummer) should be on the 6th of June 2008 at de Peppel in Zeist.