Other decarboxylation reactions from the citric acid cycle include:
Chemical decarboxylations reactions often require extensive heating in high-boiling solvents. Copper salts are often added as catalysts. Heating a carboxylic acid strongly with soda lime is also able to effect decarboxylation. Heating the product of the malonic ester synthesis with hydrochloric acid also affords decarboxylation. The addition of catalytic amounts of cyclohexen-2-one has been reported to catalyze the decarboxylation of amino acids.
Decarboxylations are especially easy for beta-keto acids due to the formation of a cyclic transition state for instance in Knoevenagel condensations. The Barton decarboxylation and Hunsdiecker reaction are radical reactions.
Kolbe electrolysis — the electrolysis of salts of carboxylic acids give the decarboxylated dimer products:
This reaction occurs via a radical mechanism as well.
WIPO ASSIGNS PATENT TO THE UNIVERSITY OF VERMONT AND STATE AGRICULTURAL COLLEGE FOR "METHOD AND SYSTEM FOR THE SELECTIVE OXIDATIVE DECARBOXYLATION OF FATTY ACIDS" (AMERICAN INVENTORS)
May 20, 2011; GENEVA, May 20 -- Publication No. WO/2011/056508 was published on May 12. Title of the invention: "METHOD AND SYSTEM FOR THE...
WIPO ASSIGNS PATENT FOR "PRODUCTION OF ALKENES BY ENZYMATIC DECARBOXYLATION OF 3-HYDROXYALKANOIC ACIDS" (FRENCH INVENTOR)
Sep 02, 2010; GENEVA, Sept. 4 -- Publication No. WO/2010/001078 was published on Jan. 07. Title of the invention: "PRODUCTION OF ALKENES BY...
US Patent Issued to BioSpring on July 19 for "Enzymatic Asymmetric Decarboxylation of Disubstituted Malonic Acids" (German Inventors)
Jul 21, 2011; ALEXANDRIA, Va., July 21 -- United States Patent no. 7,981,645, issued on July 19, was assigned to BioSpring GmbH (Frankfurt,...