David D. Wagener was born in Easton, Pennsylvania. He was captain of the Easton Union Guards from 1816 to 1829.
Wagener was elected as a Jacksonian to the Twenty-third and Twenty-fourth Congresses and elected as a Democrat to the Twenty-fifth and Twenty-sixth Congresses. He served as the chairman of the United States House Committee on Militia during the Twenty-fifth Congress. He established the Easton Bank in 1852 and was its president until his death in Easton in 1860. Interment in Easton Cemetery.