Drain may refer to:

• An exit-point for waste water or water that is to be re-circulated in fountains, pools, or drains that are used in plumbing
• Drainage, the natural or artificial removal of surface and sub-surface water from a given area
• Storm drain, a system of collecting and disposing of rain water in an urban area
• Drain STH, a disbanded female hard-rock band from Sweden
• Drain (surgery), a tube used to remove pus or other fluids from a wound
• Drain, Maine-et-Loire, a commune in Maine-et-Loire département, France
• One terminal in a field effect transistor
• Waterloo & City Line, in the London Underground, nicknamed the The Drain
• Data Drain, a fictional element and technique in the .hack universe
• Drain, Oregon, a city in Douglas County, Oregon, United States
• Drain (comics), a comic book series starring a vampire