DPH1 homolog (S. cerevisiae), also known as DPH1, is a human gene. It encodes a protein that modifies histidine-699 on eukaryotic translation elongation factor 2 to diphthamide. This modification appears to be important in the translation (genetics) of Cyclin D in ovarian cells. OVCA1 is mutated in 90% of ovarian cancers end stage, usually by loss of heterozygosity.

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