Disrupted in Schizophrenia 1 or DISC1 is a protein with a wide array of interactions. It participates in cell growth, movement, axonal growth and transport, neural positioning. Among its known partners are LIS1 and NUDEL proteins and PDE4B enzyme. Disruptions in DISC1 structure may play an important role at least in some cases of schizophrenia, however the evidence from genetic linkage and association studies suggests that variants of DISC1 do not play a significant role in most cases of schizophrenia, although DISC1 may be more important in bipolar disorder.

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