, a D-2-hydroxy-acid dehydrogenase
is an enzyme
the chemical reaction
- (R)-lactate + acceptor pyruvate + reduced acceptor
Thus, the two substrates of this enzyme are (R)-lactate and acceptor, whereas its two products are pyruvate and reduced acceptor.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with other acceptors. The systematic name of this enzyme class is (R)-2-hydroxy-acid:acceptor 2-oxidoreductase. Other names in common use include D-2-hydroxy acid dehydrogenase, and (R)-2-hydroxy-acid:(acceptor) 2-oxidoreductase. It has 2 cofactors: FAD, and Zinc.
- GREGOLIN C, SINGER TP, KEARNEY EB, BOERI E "The formation and enzymatic properties of the various lactic dehydrogenases of yeast". Ann. N. Y. Acad. Sci. 94 780–97.
- Nygaard AP "D(-)-Lactate cytochrome c reductase, a flavoprotein from yeast". J. Biol. Chem. 236 920–925.
- Tubbs PK and Greville GD "Dehydrogenation of D-lactate by a soluble enzyme from kidney mitochondria". Biochim. Biophys. Acta 34 290–291.
- The CAS registry number for this enzyme class is .
Gene Ontology (GO) codes