D-2-hydroxy-acid dehydrogenase

D-2-hydroxy-acid dehydrogenase

In enzymology, a D-2-hydroxy-acid dehydrogenase is an enzyme that catalyzes the chemical reaction

(R)-lactate + acceptor rightleftharpoons pyruvate + reduced acceptor

Thus, the two substrates of this enzyme are (R)-lactate and acceptor, whereas its two products are pyruvate and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with other acceptors. The systematic name of this enzyme class is (R)-2-hydroxy-acid:acceptor 2-oxidoreductase. Other names in common use include D-2-hydroxy acid dehydrogenase, and (R)-2-hydroxy-acid:(acceptor) 2-oxidoreductase. It has 2 cofactors: FAD, and Zinc.


  • GREGOLIN C, SINGER TP, KEARNEY EB, BOERI E "The formation and enzymatic properties of the various lactic dehydrogenases of yeast". Ann. N. Y. Acad. Sci. 94 780–97.
  • Nygaard AP "D(-)-Lactate cytochrome c reductase, a flavoprotein from yeast". J. Biol. Chem. 236 920–925.
  • Tubbs PK and Greville GD "Dehydrogenation of D-lactate by a soluble enzyme from kidney mitochondria". Biochim. Biophys. Acta 34 290–291.

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes

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