Cytidine diphosphate choline

Choline-phosphate cytidylyltransferase

In enzymology, a choline-phosphate cytidylyltransferase is an enzyme that catalyzes the chemical reaction

CTP + choline phosphate rightleftharpoons diphosphate + CDP-choline

Thus, the two substrates of this enzyme are CTP and choline phosphate, whereas its two products are diphosphate and CDP-choline.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is CTP:choline-phosphate cytidylyltransferase. Other names in common use include phosphorylcholine transferase, CDP-choline pyrophosphorylase, CDP-choline synthetase, choline phosphate cytidylyltransferase, CTP-phosphocholine cytidylyltransferase, CTP:phosphorylcholine cytidylyltransferase, cytidine diphosphocholine pyrophosphorylase, phosphocholine cytidylyltransferase, phosphorylcholine cytidylyltransferase, and phosphorylcholine:CTP cytidylyltransferase. This enzyme participates in aminophosphonate metabolism and glycerophospholipid metabolism.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes and .


  • BORKENHAGEN LF, KENNEDY EP "The enzymatic synthesis of cytidine diphosphate choline". J. Biol. Chem. 227 951–62.
  • KENNEDY EP, WEISS SB "The function of cytidine coenzymes in the biosynthesis of phospholipides". J. Biol. Chem. 222 193–214.
  • Williams-Ashman HG and Banks J "Participation of cytidine coenzymes in the metabolism of choline by seminal vesicles". J. Biol. Chem. 223 509–521.

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes

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