, a choline-phosphate cytidylyltransferase
is an enzyme
the chemical reaction
- CTP + choline phosphate diphosphate + CDP-choline
Thus, the two substrates of this enzyme are CTP and choline phosphate, whereas its two products are diphosphate and CDP-choline.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is CTP:choline-phosphate cytidylyltransferase. Other names in common use include phosphorylcholine transferase, CDP-choline pyrophosphorylase, CDP-choline synthetase, choline phosphate cytidylyltransferase, CTP-phosphocholine cytidylyltransferase, CTP:phosphorylcholine cytidylyltransferase, cytidine diphosphocholine pyrophosphorylase, phosphocholine cytidylyltransferase, phosphorylcholine cytidylyltransferase, and phosphorylcholine:CTP cytidylyltransferase. This enzyme participates in aminophosphonate metabolism and glycerophospholipid metabolism.
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes and .
- BORKENHAGEN LF, KENNEDY EP "The enzymatic synthesis of cytidine diphosphate choline". J. Biol. Chem. 227 951–62.
- KENNEDY EP, WEISS SB "The function of cytidine coenzymes in the biosynthesis of phospholipides". J. Biol. Chem. 222 193–214.
- Williams-Ashman HG and Banks J "Participation of cytidine coenzymes in the metabolism of choline by seminal vesicles". J. Biol. Chem. 223 509–521.
- The CAS registry number for this enzyme class is .
Gene Ontology (GO) codes