, a cysteine-tRNA ligase
is an enzyme
the chemical reaction
- ATP + L-cysteine + tRNACys AMP + diphosphate + L-cysteinyl-tRNACys
The 3 substrates of this enzyme are ATP, L-cysteine, and tRNA(Cys), whereas its 3 products are AMP, diphosphate, and L-cysteinyl-tRNA(Cys).
This enzyme belongs to the family of ligases, specifically those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-cysteine:tRNACys ligase (AMP-forming). Other names in common use include cysteinyl-tRNA synthetase, cysteinyl-transferRNA synthetase, cysteinyl-transfer ribonucleate synthetase, and cysteine translase. This enzyme participates in cysteine metabolism and aminoacyl-trna biosynthesis.
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes , , and .
- McCorquodale DJ "The separation and partial purification of aminoacyl-RNA synthetases from Escherichia coli". Biochim. Biophys. Acta 91 541–548.
- The CAS registry number for this enzyme class is .
Gene Ontology (GO) codes