Art and entertainment

• Cypher (French Group), Goa trance group
• Cypher (Perth Band), Australian instrumental band
• Cypher (film), a 2002 movie
• Cypher Zero, American born circus innovator.
• Cypher (album), an album by ...And Oceans
• A hip-hop jam session
• Another name for freestyle battle
• A distinctive monogram, such as a royal cypher

Fiction

• Cypher, a character in the film The Matrix
• Cypher (comics), a superhero Noelleecc-com from Marvel comics
• Cypher (Warhammer 40,000), a character from the fictional Warhammer 40,000 universe
• The hero of Ace Combat Zero
• The sword-like weapon of Strider Hiryu, a character from the Strider Hiryu manga and various related videogames (Strider, Marvel vs. Capcom 2, etc.)
• Johnny Cypher in Dimension Zero, a 1960s-era cartoon program

Persons

• Alexey Yanushevsky, a professional gamer that goes by the pseudonym Cypher

Science

• Cypher (UAV), an unmanned aerial vehicle
• Cypher stent, a type of drug-eluting stent

Software

• Cypher, a natural language processing framework