Cyme, ancient Greek city of W Asia Minor, on the Ionian Sea and N of the present Smyrna in W Asian Turkey. It was the largest and most important of the 12 cities of Aeolis. In the late 5th cent. B.C., Cyme struggled to be free of Persian domination but was only intermittently successful. Later it was a city of the Seleucids and ultimately of Rome.