Compared to other new age artists, Cusco's music is quite melodic and usually energetic, and the band focuses on creating a fusion of modern and ethnic styles with classical music influences and solid rock music sensibilities. Most of the ethnic instruments are keyboard-generated, giving the music a synthetic quality. Some of their music is used as pre-show background music in Epcot prior to IllumiNations: Reflections of Earth, and has been used as bumper music for the popular American syndicated radio program, Coast to Coast AM, as well as several television advertisements, including a Bud Ice beer commercial. Additionally, Cusco composed and performed the music for the German television special Sielmann 2000.
During their years on Higher Octave from 1988 to the present, Cusco has sold well over two million albums (the Apurimac series alone selling well over one million), despite their genre remaining relatively underground. Their albums consistently rank high on the instrumental/new age music sales charts.