Infections can be extremely difficult to treat because of other creatures, such as corals and other invertebrates, which will not survive standard treatments. Ideally fish with Cryptocaryon are quarantined in a hospital tank, where they can be treated with a copper salt or using hyposalinity. The display tank needs to be kept clear of fish for 6-9 weeks, the longer the better. This gives time for the encysted tomonts to release infectious theronts, which die within 24-48 hours when they cannot find a host.
Cryptocaryon irritans was originally classified as Ichthyophthirius marinus, but it is not closely related to the other species. It belongs to the class Prostomatea, but beyond that its placement is still uncertain.