In enzymology, a creatinase is an enzyme that catalyzes the chemical reaction

creatine + H2O rightleftharpoons sarcosine + urea

Thus, the two substrates of this enzyme are creatine and H2O, whereas its two products are sarcosine and urea.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amidines. The systematic name of this enzyme class is creatine amidinohydrolase. This enzyme participates in arginine and proline metabolism.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes and .


  • ROCHE J, LACOMBE G, GIRARD H "[On the specificity of certain bacterial deguanidases generating urea and on arginindihydrolase.]". Biochim. Biophys. Acta. 6 210–6.
  • Yoshimoto T, Oka I, Tsuru D "Purification, crystallization, and some properties of creatine amidinohydrolase from Pseudomonas putida". J. Biochem. 1381–3.

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes

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