Rosselli also spent some time in Lucca, where he painted several altar-pieces for various churches. A picture attributed to him, taken from the church of St. Girolamo at Fiesole, is now in the National Gallery of London. It is a large retable, with, in the center, St. Jerome in the wilderness kneeling before a crucifix, and at the sides standing figures of St. Damasus and St. Eusebius, St. Paula and St. Eustochium; below is a predella with small subjects. Though dry and hard in treatment, the figures are designed with much dignity.
The Berlin Gallery possesses three pictures by Rosselli: The Virgin in Glory, The Entombment of Christ, and The Massacre of the Innocents. In 1480 Rosselli, together with the chief painters of Florence, was invited by Pope Sixtus IV to Rome to assist in the painting of the frescoes in the Sistine Chapel. Three of these were executed by him The Destruction of Pharaohs Army in the Red Sea, Christ Preaching by the Lake of Tiberias, and The Last Supper. Rosselli's Sistine frescoes were partly painted by his assistant and son in law Piero di Cosimo, who was so called after Cosimo Rosselli. His chief pupil was Fra Bartolomeo.