Constance was the only daughter of Bohemund II of Antioch by his wife Alice, princess of Jerusalem. She became princess of Antioch when she was only four-years-old, under the regency of Baldwin II of Jerusalem (1130-1131) and Fulk of Jerusalem (1131-1136). Her mother Alice did not want the principality to pass to Constance, preferring to rule in her own name. Alice attempted to ally with the Muslim atabeg of Mosul, Zengi, offering to marry Constance to a Muslim prince, but the plan was foiled by Alice's father Baldwin, who exiled her from Antioch. In 1135 Alice attempted once again to take control of the principality, and sought a husband for Constance in Manuel Comnenus, at that time the heir to the Byzantine throne. Fulk exiled her again and re-established the regency for Constance. In 1136, while still a child, Constance was married to Raymond of Poitiers, whom the noble supporters of the regency had secretly summoned from Europe; Alice was tricked into believing Raymond was going to marry her, and, humiliated, left Antioch for good when the marriage was performed. From this union three children were born:
According to some sources , Constance and Raynald had another daughter, Jeanne, possibly the second wife of Boniface I of Montferrat.
Raynald was captured in 1160 and spent the next sixteen years in a prison in Aleppo. A dispute arose between Constance and her son, Bohemund, when Bohemund tried to seize power in Antioch. A riot broke out, and Constance was exiled from the city. She died in 1163.