Nicole brown met O.J. while she worked as a waitress the he patroned. Nicole Brown was several months pregnant when O.J. Simpson left his wife ,Margeurite, and family. Margeurite did not know about the affair. O.J.'s first wife , Marguerite, stated that she seen Nicole brown driving by their family home several times before she knew who it was. Brown and O. J. Simpson were married on February 2, 1985, after his retirement from professional football. They had two children together, Sydney Brooke Simpson (born October 17, 1985) and Justin Ryan Simpson (born August 6, 1988). The marriage lasted seven years, ending when Nicole divorced him in 1992, citing an "abusive relationship".
On the morning of June 13 1994, neighbors, alerted by a barking dog, found the mutilated bodies of Nicole Simpson and her friend Ronald Goldman in the enclosed front courtyard of her condo on South Bundy Drive in the Brentwood area of Los Angeles. Goldman was a waiter at the restaurant Mezzaluna, where Nicole and her family had dined that evening. He was at her condominium to return glasses that Nicole's mother, Juditha, had left there by accident. Both Goldman and Nicole had been stabbed multiple times; Nicole Simpson's head was nearly severed from her body. Both had defensive wounds on their hands. At the time of the murders, Sydney and Justin, her children with O. J., were asleep inside the condominium.
O. J. Simpson was arrested and charged with both murders; he was acquitted of these crimes in a criminal trial by jury. However, in a subsequent civil trial, he was found liable for the deaths of his ex-wife and Goldman and ordered to pay $33,500,000 (USD) to the families of Brown and Goldman.
In 1994, Nicole Simpson's sister Denise Brown established The Nicole Brown Charitable Foundation in Nicole's memory, to assist victims of domestic violence. 
During the murder trial, Nicole's parents looked after Sydney and Justin. In 1996, a judge granted Simpson's petition to give him full custody of the children. Nicole's parents continued unsuccessfully to fight for custody of Sydney and Justin.
On the night of the murder, Nicole's mother called the Mezzaluna at 9:30 pm to inquire if her sunglasses were left at the restaurant. Nicole called at 9:35 pm and asked specifically for Ron Goldman, presumably to ask him to deliver the sunglasses to her that night. Between leaving the restaurant and arriving at Nicole's around 10:30 pm, Ron stopped at his apartment to change clothes and possibly shower. Nicole was found wearing a short black dress. Inside her home there were lit candles and music playing. There was speculation that their relationship was romantic, but there was no conclusive evidence.
After the murders, pictures were published by the National Enquirer of Brett Shaves and Nicole Simpson in a hot tub together naked. Other photos came out of the two of them in Mexico together.