The Comparative Toxicogenomics Database (CTD) is a public website and research tool that curates scientific data describing relationships between chemicals, genes, and human diseases.
The database is maintained by the Department of Bioinformatics at The Mount Desert Island Biological Laboratory in Salisbury Cove, Maine.
The etiology of many chronic diseases involves interactions between environmental factors and genes that modulate important physiological processes. Chemicals are an important component of the environment. Conditions such as asthma, cancer, diabetes, hypertension, immunodeficiency, and Parkinson's disease are known to be influenced by the environment; however, the molecular mechanisms underlying these correlations are not well understood. CTD may help resolve these mechanisms.
Users can search CTD to explore scientific data for chemicals, genes, diseases, or interactions between any of these three concepts. Currently, CTD integrates toxicogenomic data for vertebrates and invertebrates, including 59,000 chemicals, 1.2 million gene and protein sequences (and their associated Gene Ontology and KEGG pathway annotations), 83,000 taxonomic terms, and 6,000 human diseases to produce a unique resource for the cross-species analysis of chemical, gene, and disease interactions.
CTD integrates data from or hyperlinks to these databases:
The Comparative Toxicogenomics Database facilitates identification and understanding of chemical-gene-disease associations: arsenic as a case study.(Research article)
Oct 09, 2008; Authors: Allan P Davis ; Cynthia G Murphy ; Michael C Rosenstein ; Thomas C Wiegers ; Carolyn J Mattingly...
Biomax Informatics Collaborates with the Mount Desert Island Biological Laboratory MDI To Integrate MDI's Curated Comparative Toxicogenomics Database with the BioXM Knowledge Management Environment.
Aug 11, 2008; Biomax Informatics and the Mount Desert Island Biological Laboratory (MDI) announced that Biomax will integrate MDI's Comparative...