Autoimmune hemolytic anemia
(AIHA) is a type of hemolytic anemia
where the body's immune system attacks its own red blood cells
(RBCs), leading to their destruction (hemolysis
and associated complement system
components become fixed onto the RBC
surface. These antibodies
can be detected with the direct antiglobulin test
, also known as the direct Coombs test
. AIHA can also be induced by several drugs including methyldopa
Autoimmunity must not be confused with alloimmunity.
can be intravascular or extravascular.
Red blood cell lysis occurs in the circulation as a result of activation of the complement system cascade.
Red Blood Cells that are coated with antibodies are specifically recognised in the reticuloendothelial system and destroyed by macrophages.
Warm antibody autoimmune hemolytic anemia
Cold antibody autoimmune hemolytic anemia
Mixed-type autoimmune hemolytic anemia