López is a common surname in the Spanish language (it can also lack the acute accent). It was originally a patronymic, meaning Son of Lope, Lope itself being a Spanish given name deriving from Latin lupus, meaning wolf. The surname is first attested in Old Castile in the heart of Spain, where the name originated in Visigothic times , however the name is not of Germanic language origin, but from Latin. Its Portuguese equivalent is Lopes, its Italian equivalent is Lupo, its Romanian equivalent is Lupescu. López is the most common Hispanic surname in the United Kingdom.

• Adamari López, Puerto Rican actress
• Adolfo López Mateos, Mexican president
• Al Lopez, American baseball catcher and manager
• Albie Lopez, American baseball pitcher
• Alfonso López Caballero, Colombian politician
• Alfonso López Michelsen, President of Colombia
• Alfonso López Pumarejo, President of Colombia
• Alfonso López Trujillo, Colombian Cardinal
• Aliuska López, Cuban-Spanish athlete
• Andrés Manuel López Obrador, Mexican politician
• Andrés Rodrigo López, Italian cellist
• Antonio López de Santa Anna (1794-1876), Mexican general and dictator
• António López García, Spanish painter and sculptor
• Antonio López Guerrero, Spanish football player
• Antonio López-Istúriz White, Spanish politician member of the European Parliament
• Awilda Lopez, American criminal
• Barry Lopez, American writer
• Brook Lopez,American basketball player,twin of Robin Lopez
• Cachao López, Cuban mambo musician and composer
• Carlos Antonio López, Paraguayan president
• Carlos J. Lopez, Puerto Rican Reggaeton Artist and Producer
• Claudio López, Argentine footballer
• Danny Lopez, U.S. boxer
• David López-Zubero, Spanish Olympic swimmer
• Diego López Rodríguez, Spanish football player
• Donald Lopez, American Air Force fighter and test pilot
• Eli Lopez, American Artist (painter)
• Esteban Lopez, College Football Player at Tennessee-Chattanooga
• Federico Lopez, Puerto Rican basketball player
• Feliciano López, Spanish tennis player
• Felipe López (basketball)
• Felipe López (archer)
• Felipe López (baseball player)
• Fernão Lopez, first permanent resident of the island of Saint Helena
• Francisco Solano López, Paraguayan president
• Francisco Solano López, Argentine comics artist
• Gabe Lopez, American singer-songwriter and producer
• García López de Cárdenas, Spanish conquistador
• George Lopez, American comedian
• George A. Lopez, American academic
• Gerry Lopez, American surfer and occasional film actor
• Gustavo Adrián López, Argentine football player
• Hector Lopez, Panamanian baseball player
• Hermógenes López, Venezuelan president
• Israel López (football player), Mexican football player
• James Lopez Watson, American judge and politician
• Javy López, Puerto Rican baseball player
• Jennifer Lopez, American actress, singer, dancer and designer
• Jennifer Lopez (meteorologist), meteorologist and co-host on The Weather Channel
• Jesús López Cobos, Spanish conductor
• Joaquín López-Dóriga, Spanish-Mexican journalist
• José Celestino López, Venezuelan baseball player
• José López Portillo, Mexican president
• José Luis López Ramírez, Costa Rican football player
• Jose M. Lopez, American Medal of Honor recipient
• Juan Antonio Lopez, Mexican boxer
• Juan Fernando López Aguilar, Spanish politician
• Kathryn Jean Lopez, American conservative columnist
• Leon Lopez, British actor
• Lourdes Lopez, former New York City Ballet principal dancer
• Luis A. López, American poet
• Luscious Lopez,
• Lynda Lopez, American news anchor
• Manuel Isaias Lopez, Mexican child psychiatrist
• Marco Lopez, American politician
• Mara Lopez, Filipina actress
• Marga López, Argentine-Mexican actress
• Mario López, American actor
• Martin Lopez, Swedish heavy metal drummer
• Martín López-Vega, Spanish Asturian language writer
• Maxi López, Argentine football player
• Michael Lopez-Alegria, American astronaut
• Miguel López de Legaspi, Spanish explorer
• Nadia López, Mexican singer and reality television star
• Nancy Lopez, American golf player
• Narciso López, Venezuelan soldier and Cuban independence fighter
• Nicolás de Jesús López Rodríguez
• Nicolás Lindley López, Peruvian military commander
• Oscar Lopez, Chilean-Canadian folk guitarist
• Oswaldo López Arellano, President of Honduras from 1963-1971 and 1972-1975
• Patxi Lopez, Basque socialist politician
• Pedro Lopez, Colombian serial killer accused of killing more than 300 people
• Pero López de Ayala, Spanish statesman
• Polyana López, Argentine actress
• Priscilla Lopez, American singer, dancer, and actress
• R. Edward Lopez, American newsman and morning radio personality
• Raúl López, Spanish basketball player
• Renato López, Mexican musician
• Ricardo López, Mexican boxer
• Ricardo López Felipe, Spanish football player
• Ricardo López Murphy, Argentine economist and politician
• Ricky Lopez, Puerto Rican singer, ex-Menudo
• Robert Lopez, composer and lyricist of musicals
• Robin Lopez, American basketball player, twin of Brook Lopez
• Rodrigo Lopez may refer to:
• Rodrigo Muñoz López, a major league starting pitcher for the Colorado Rockies
• Rodrigo Lopez, physician to Queen Elizabeth I
• Rodrigo Lopez, a Mexican-American soccer player
• Rosa López, Spanish singer and dancer of Operación Triunfo
• Ruy López de Segura, Spanish priest after whom the Ruy López opening is named
• Ruy López de Villalobos, Spanish explorer
• Santos López Pelegrín, Spanish journalist
• Sergi López, Spanish actor
• Sergio López Miró, Spanish swimmer
• Sky Lopez
• Steven Lopez, 2000 and 2004 USA Olympic Tae Kwon Do Gold Medalist
• Sue Lopez, English women-footballer, manager, coach and advocate of the women's game
• Trini Lopez, American musician
• Vincent Lopez American bandleader and pianist.
• Yolanda Lopez, American artist