The protein CTCF is involved in repressing expression of the gene, by binding to the H19 imprinting control region (ICR) along with Differentially-methylated Region-1 (DMR1) and Matrix Attachment Region -3 (MAR3). These three DNA sequences bind to CTCF in a way that limits downstream enhancer access to the Igf2 region. The mechanism in which CTCF binds to these regions is currently unknown, but could include either a direct DNA-CTCF interaction or it could possibly be mediated by other proteins
Findings in Molecular Diagnostics Reported from Institute for Clinical and Experimental Pathology.(Clinical report)
Mar 19, 2011; Data detailed in 'Nucleotide extension genotyping by high-resolution melting' have been presented. According to a study from the...