Clarice had extensive experience acting in the soap opera genre. She played a baby nurse & a college dean on the CBS soap opera, Love of Life, in the early 1960s. She played Theodora Rostand on NBC's The Doctors in 1966, then moved on to "Dark Shadows," then created the role of "Mary Lou Northcote" on the CBS soap opera, The Secret Storm in 1970. She signed a contract to play "Amy Snowden" on CBS-TV's Where the Heart Is, a role she played until the series left the air in 1973.
She moved over to One Life to Live on ABC playing "Hattie Frederichs," then back to CBS to As the World Turns playing "Marion Connelly, R.N." & finally to Guiding Light where she played "Edith Spurrier".
Clarice's primetime TV credits include guest roles on "The Defenders," "The Nurses," "East Side/West Side," "Armstrong Circle Theatre," "Dupont Show of the Month," "U.S. Steel Hour," "Studio One," "N.Y.P.D." and the 1967 TV drama special, "The Crucible,"
Clarice Blackburn appeared in the motion pictures "The Violators," "Pretty Poison," "Night of Dark Shadows" and "Man on a Swing".
Clarice has appeared in many theatre productions, most notably on Broadway in Juno, The Desk Set, The Happy Time and The Miracle Worker. In addition, Clarice won an Obie award for her work in off-Broadway's Exhaustion of our Son's Love.
She died in New York City from cancer, aged 74.