, a citrate-CoA ligase
is an enzyme
the chemical reaction
- ATP + citrate + CoA ADP + phosphate + (3S)-citryl-CoA
The 3 substrates of this enzyme are ATP, citrate, and CoA, whereas its 3 products are ADP, phosphate, and (3S)-citryl-CoA.
This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is citrate:CoA ligase (ADP-forming). Other names in common use include citryl-CoA synthetase, citrate:CoA ligase, and citrate thiokinase. This enzyme participates in citrate cycle (tca cycle).
- Lill U, Schreil A, Eggerer H "Isolation of enzymically active fragments formed by limited proteolysis of ATP citrate lyase". Eur. J. Biochem. 125 645–50.
- Aoshima M, Ishii M, Igarashi Y "A novel enzyme, citryl-CoA synthetase, catalysing the first step of the citrate cleavage reaction in Hydrogenobacter thermophilus TK-6". Mol. Microbiol. 52 751–61.
- The CAS registry number for this enzyme class is .
Gene Ontology (GO) codes