Since chrysin is available as an herbal supplement, some users, for instance body builders, are taking chrysin with the hope of raising testosterone levels or stimulating testosterone production. One study listed below did not find chrysin supplementation to lead to any significant increase in testosterone production.
Chrysin was once believed to be an effective aromatase inhibitor, decreasing the levels of estrogen in the body. However, there is growing consensus that chrysin has no effect on estrogen levels in either animals or humans. . Early evidence was reported in the early 1980's through in vitro studies (in the laboratory, as opposed to in the body) . Unfortunately, follow-up studies determined that cell membranes effectively block chrysin from entering the cells and having any effect at all on estrogen levels in biological organisms . In vivo (in the body) studies involving biological organisms lend support to the observation that chrysin has no effect on estrogen levels, but may have other detrimental effects to the body, particularly to thyroid function . For instance, a 30 day study administered chrysin to four groups of mice both orally and via injection to examine chrysin's effect on serum estrogen levels. The results showed that chrysin had no effect on estrogen levels. Further, the mice treated with chrysin became considerably fatter, possibly due to chrysin's ability to disrupt thyroid function.. Another study on rats administered 50 mg of chrysin per kg body weight, considerably more than found in dietary supplements. Chrysin was found to have no ability to inhibit aromatase, possibly due to poor aborption or bioavailablity .
In herbal medicine, chrysin is recommended as a remedy for anxiety, but there are no controlled data in humans available.
Many herbal remedies that contain chrysin tout their value as a libido-increasing supplement. There is no evidence so far in vivo.
Chrysin demonstrated cell toxicity and inhibition of DNA synthesis at very low concentrations in a normal trout liver cell line.
Luteolin and Chrysin Differentially Inhibit Cyclooxygenase-2 Expression and Scavenge Reactive Oxygen Species but Similarly Inhibit Prostaglandin-E^sub 2^ Formation in RAW 264.7 Cells1
Jun 01, 2006; ABSTRACT Inflammation and oxidative stress are associated with cancer, atherosclerosis, and other chronic diseases. Dietary...
The Effects of Chrysin, a Passiflora incarnata Extract, on Natural Killer Cell Activity in Male Sprague-Dawley Rats Undergoing Abdominal Surgery
Apr 01, 2008; Chrysin, a passion flower extract, may be beneficial because of its potential to attenuate surgical suppression of natural...