Chartiers Creek winds from its headwaters in Washington County through Allegheny County, where it meets the Ohio River at McKees Rocks and Pittsburgh's West End, three miles west of the Point at Pittsburgh. The creek was named after Pierre Chartiers, a trapper of French and Native American parentage who established a trading post at the mouth of the creek in 1743.
Acid mine drainage, agricultural and industrial runoff, and sewer overflow made Chartiers Creek one of the most polluted watersheds in Pennsylvania. Although improvements have been made, the watershed remains significantly impaired.
Plans have been considered to establish the course of Chartiers Creek as a greenway including a multi-use path that would stretch from Canonsburg Lake to the Ohio River. Such a path could eventually provide connections with the Montour Trail near Lawrence, the Panhandle Trail near Carnegie, and the Three Rivers Heritage Trail in McKees Rocks.