Nicknamed, 'The Enforcer', Pancamo is introduced in the show's second season. He is an Italian-American gangster serving time for tying a woman in a bag and throwing her into the ocean. Extremely muscular, he is primarily an enforcing member of the titular prison's Italian gang until he is asked to take over by Mafia boss Antonio Nappa. Pancamo runs the gambling and drug businesses in Oz. He is one of the most feared men in Oz, but makes several mistakes as a soldier and as a leader of the Italians. But he does find a way to come out of each situation through his toughness and is one of the few leaders in Oz to make it through the duration of the show.
Pancamo mainly acts as a soldier, second in command to Peter Schibetta. He does not really like the black inmates who work in the kitchen and often calls them "Moolies". He helps Schibetta try to kill Simon Adebisi, leader of the Homeboys, the prison's black gang. Adebisi is able to defeat both of his attackers and knocks Pancamo out with an industrial kitchen tool and a can of fruit. Adebisi rapes Schibetta but Pancamo will not confirm that it has happened since he was unconscious. The black inmates, especially Kenny Wangler and Junior Pierce, make fun of him often for being beaten by Adebisi and berate him by calling him a "guinea".
Things look up for Pancamo when Nappa arrives and brings the Italians back into a seat of power. After taking Adebisi off of heroin for the time being with the help of staff member Lenny Burrano, Nappa and Pancamo steal Adebisi's drugs and offer them a deal. Nappa, Pancamo, and Don Zanghi tell Wangler that if he kills Kipekemie Jara, an African man who has Adebisi under control, that he can work as their partner and they will call a truce. Wangler kills Jara and the Italians accept the Homeboys as their partners.
This season starts with Adebisi being released from the psych ward and coming back to work in the Italian's kitchen. Pancamo is often cautious with Nappa and advises him on how to deal with the Homeboys. He often reminds Wangler not to get too cocky whenever he deals with ordering around the Italians. When Nappa gets infected with HIV, he turns control over to Pancamo. In the meantime, Chucky finds out that Nappa is publishing a book detailing all the mob hits and criminal acts that have taken place over the last century. With authority from the outside family, Pancamo has the book destroyed and has gay inmate Nat Ginzburg murder Nappa.
Adebisi comes to Pancamo, asking to be partners in the drug trade. Pancamo tells him that if he kills the other Homeboys, he can be their partner. Adebisi burns Poet and Pierce first and then Wangler is left without any help and at Adebisi's mercy. As a result, Pancamo, Adebisi, and Hernandez now are three way partners in the drug trade. Pancamo also represents the Italians in the boxing tournament. After easily knocking out a Biker in round 1 of the first fight, Pancamo somehow loses to Cyril O'Reilly, the younger and mentally handicapped brother of Ryan O'Reilly. Wondering how he lost to an inmate who he had over 60 lbs. on, he is told that the fight was fixed by a Russian mobster Yuri Kosygin who is serving time in Oz. With advice from O'Reilly, Pancamo gets Kosygin placed in Isolation by informing him that Nikolai Stanislofsky has informed people of his involvement in drugging the water. Later, racial tension brews in Oz, and Pancamo tells Adebisi to cool the rhetoric or else they will be unable to push drugs if the prison is locked down. Adebisi refuses and Hernandez points out that he is in a Loco state. Vern Schillinger also calls Pancamo and all the other White inmates to a meeting claiming that they must all stick together because they are bound by the color of their skin. Warden Glynn however locks Oz down going into the new millennium.
Oz is no longer locked down and things for the time being go back to normal until a shooting takes place in Em City. In Em City, Pancamo then sponsors new Italian inmate Ralph Galino a contractor who is imprisoned for his alleged part in a building collapse. Galino then reveals that he has no criminal connections, works an honest job, and despises Italian-Americans like Pancamo who give the rest of them a stereotypical criminal image. This has Pancamo cause the Italian inmates to ignore Galino as he is unable to provide any use to them. Hernandez decides that the Latinos will join the White inmates side of the racial tension issue and snitches on Adebisi for getting the gun inside Oz. In the meantime a new Latino inmate Enrique Morales arrives in Oz. Because Morales comes in with credibility and Pancamo thinks Hernandez is on the verge of a mental breakdown, he prefers that Enrique run the Latinos in the drug trade giving him Hernandez's third if Raoul is eliminated. Morales agrees that Hernandez is going "Loco" and then has Bob Rebadow kill him. In the meantime, a new inmate Desmond Mobay, a Jamaican inmate wants into the drug game. Unknowing to Morales, Adebisi, and Pancamo, Mobay is actually an African American narcotics detective named Johnny Basil. They all ask Mobay to do a variety of tests to prove that he can be a gangster such as taking punches from Pancamo and snorting heroin (which undercover police are forbidden to do) among other things. A straw poll is then taken to determine if Mobay is worthy where Pancamo votes yes, Adebisi votes no, and Morales abstains. They resolve that he is a worthy ally under the condition that he kills an inmate. Mobay does so and for the time being has Pancamo's support. Things get even better in the drug trade when new unit manager, an African American named Martin Querns comes to Oz. Querns likes Adebisi and his followers and tells Adebisi that they can have unrestricted drug dealing if his supporters prevent violence from happening. He enforces this by making Pancamo, Morales, and Adebisi trustees. Pancamo likes this system because it can allow Em City to be like Little Italy in the old days. In the mean time, Hank Schillinger, son of Aryan Brotherhood leader Vernon Schillinger, beats a murder charge for killing the son of Tobias Beecher. Beecher comes to Pancamo and hires him to arrange a hit on Hank, which he does after Beecher promptly pays him. Things get complicated, however, when several of the white inmates and guards are transferred out. All the new guards are black and all the new inmates are black and allied with Adebisi. When Pancamo's cellmate Don Zanghi is thrown into solitary confinement, Pancamo is beaten by the black guards for protesting. Pancamo and Morales both talk to Adebisi about how they are disappointed with the way things are set up as a result. Adebisi tells them that he now controls the drug trade completely, and when they threaten to go to war, Adebisi first points out they will both lose since Em City is now overwhelmingly Black and then tells them that he and Querns have arranged for the Italian and Latino inmates to also be transferred out. In Unit B, Schillinger suggests to Pancamo and Hoyt that an all-white unit should be created which Tim McManus ardently rejects.
Adebisi has been killed by Kareem Said and Em City is running back to normal. With no leader the Homeboys are out of the drug trade so Pancamo and Morales are both cruising comfortably with the drug trade. Things get complicated when the Homeboys are brought back into the fold by Burr Redding. The Italians and Latinos offer a partnership that Redding rejects. As a result, Pancamo and Morales tell ex-communicated Homeboy and Five-Percenter Supreme Allah whom Redding despises that he can be their partner if he kills Redding. Supreme says yes with time so that he can get the approval of the other Homeboys. In the meantime, Morales frames Redding for murdering a Chinese refugee and as a result Redding plans his own attack on the Latino and Italian inmates. The Italians and Latinos are playing basketball in the gym when the Homeboys ambush them and there would have been a number of dead inmates had Augustus Hill not tipped off the S.O.R.T. team. Supreme Allah then says to Pancamo he will get Hill to kill Redding since they are not on good terms for the time being. Things backfire though when Supreme Allah dies and Redding is back in full swing against the Italian and Latino inmates.
Pancamo is called to an interrogation by FBI agent Pierce Taylor, who tells him that an Italian hitman named Gaetano Cincetta has implicated him in a hit on Hank Schillinger. Pancamo denies everything and then tells Tobias Beecher that if he is asked by Vern Schillinger what has happened, he will not implicate him. The Aryan Brotherhood attacks Pancamo after calling him an ethnic slur in the gym. As Pancamo prepares to assault Schillinger, James Robson approaches him from behind and stabs him in the side, putting him in the hospital. Schibetta then tries for revenge, but is instead gang-raped by the Aryans.
At the end of the season, Pancamo nearly dies in the hospital from a staph infection brought on by poor medical treatment, but he survives thanks to Oz's chief physician, Dr. Gloria Nathan.
Pancamo is out of the hospital and helps the Italians retake the drug trade. Ryan O'Reilly lies about Peter Schibetta wanting to curse the Italians with the evil eye but Pancamo and Urbano believe him and kill Peter by removing his eye. Pancamo also sees that James Robson has been ousted from the Aryan Brotherhood, so he attacks him in the library. Robson seeks protection from Wolfgang Cutler, who makes him his sex slave. Pancamo tries to kill Robson, but Cutler steps in and warns him off.
When Redding takes the Homeboys to work as telemarketers, Glynn gives Pancamo control of the kitchen under the condition that he stays away from the Aryans. In the gym, Pancamo, Urbano, and the other Italians approach Robson with an offer. They tell him that if he kills Cutler, they will forgive him. Robson hangs Cutler, making it look like a suicide. Pancamo is then approached by Redding, who asks him to stop any attempt the Homeboys do at dealing drugs so they can come back to work as telemarketers. Chucky gladly does so and has one of Poet's connections killed on the outside. The Italians then discover a new inmate selling marijuana brownies and they kill him (since they believed that he would steal all of their profits while selling the brownies).