Determined to start living a normal life as much as possible, the brothers settled on a plantation, bought slaves, and adopted the name "Bunker". On April 13, 1843, they married two sisters: Chang to Adelaide Yates and Eng to Sarah Anne Yates. Chang and his wife had 10 children; Eng and his wife had 11. In time, the wives squabbled and eventually two separate households were set up just west of Mount Airy, North Carolina in the community of White Plains – the twins would alternate spending three days at each home. During the American Civil War Chang's son Christopher and Eng's son Stephen both fought for the Confederacy. The twins died on the same day in 1874. Chang, who had been in declining health for several years, died first; Eng died one hour later.
The fused liver of the Bunker brothers is currently preserved and on display at the Mütter Museum in Philadelphia, Pennsylvania. Numerous references about the twins, including some of their personal artifacts and their travel ledger, are preserved in the North Carolina Collection Gallery in Wilson Library at the University of North Carolina at Chapel Hill. The original watercolor portrait of Chang and Eng from 1836 is also preserved in the North Carolina Collection Gallery.
The short story The Siamese Twins by Mark Twain was based on the Bunkers. In 1996, BBC Radio 4 broadcast a 90-minute radio play called "United States" about the lives and deaths of Chang and Eng Bunker. Writer was Tony Coult and director Andy Jordan. Transmission was on 17 June, with a cast that included Bert Kwouk and Ozzy Youe as the twins. A Singapore musical based on the life of the twins, Chang & Eng was directed by Ekachai Uekrongtham and written by Ming Wong with music by Ken Low. Chang & Eng premiered in 1997 and has since been performed around Asia, starring Robin Goh as Chang Bunker, Sing Seng Kwang as Eng Bunker and Selena Tan as their mother Nok. Subsequent productions starred RJ Rosales as Eng Bunker. The best-selling and multiple-award-winning 2000 novel, Chang and Eng, by Darin Strauss, was based on the life of the famous Bunker twins. The film rights to the novel were purchased by award winning filmmaking team Gary Oldman and Douglas Urbanski. Oldman is currently working on the screenplay and will also direct. The main character of Jeanne DuPrau's 2006 book The Prophet of Yonwood, Nickie, finds a signed photo of the twins in her great-grandfather's house.