Cefpodoxime

{{drugbox | | IUPAC_name = (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-
2-methoxyimino-acetyl]amino}-3-(methoxymethyl)-
8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-
carboxylic acid | image = Cefpodoxime.svg | width = 250 | CAS_number = 82619-04-3 | ATC_prefix = J01 | ATC_suffix = DD13 | PubChem = 6335986 | DrugBank = | C = 15 | H = 17 | N = 5 | O = 6 | S = 2 | molecular_weight = 427.458 g/mol | bioavailability = 50% | protein_bound = 21% to 29% | metabolism = Negligible. Cefpodoxime proxetil is metabolized to cefpodoxime by the liver | elimination_half-life = 2 hours | excretion = Renal, unchanged | pregnancy_AU = B1 | pregnancy_US = B | legal_AU = | legal_CA = | legal_UK = | legal_US = Rx-only | routes_of_administration = Oral }} Cefpodoxime (marketed as the prodrug cefpodoxime proxetil by Pharmacia & Upjohn under the trade name Vantin, is an oral third generation cephalosporin antibiotic. It is active against most Gram positive and Gram negative bacteria. Notable exceptions include Pseudomonas aeruginosa, Enterococcus, and Bacteroides fragilis. It is commonly used to treat acute otitis media, pharyngitis, and sinusitis. It also finds use as oral continuation therapy when intravenous cephalosporins (such as ceftriaxone) are no longer necessary for continued treatment. Pfizer, the parent company of Pharmacia & Upjohn, markets Cefpodoxime proxetil under the trade name Simplicef for veterinary use. The dose range in dogs is 5–10 mg/kg body weight, administered orally, once a day. In India, for children it is sold under the trade name of PECEF (Dr Reddy's) in 50mg & 100mg DT & DS forms (FGP) and for adult, it is sold under the trade name of Doxicef 200 (Lupin) in 200mg.