In Santa Fe the river first turns south, then east and finally north-east, passing by the city of Carcarañá. It receives the waters of the Cañada de Gómez (near the city of the same name, at ), develops cascades and becomes encased in ravines up to 20 m high. It then turns north and empties into the Coronda River, south of Gaboto (the Coronda then promptly empties into the Paraná River).
The Carcarañá basin comprises 2% of the territory of Santa Fe and 4% of its population lives within it. It has a total length of 240 km and it is navigable only by medium ships. It passes by or near the cities and towns of Inriville, Los Surgentes and Cruz Alta in Córdoba, and Arteaga, San José de la Esquina, Los Nogales, Arequito, Los Molinos, Casilda, Carcarañá, Andino and Gaboto in Santa Fe, traversing one of the richest agricultural districts in the world.
The Carcarañá's potential for the generation of hydroelectricity was taken advantage of since the 19th century and until the 1930s.