The Canals of Hering
, or intrahepatic bile ductules
, are part of the outflow system of exocrine bile
product from the liver.
They are found between the bile canaliculi
and interlobular bile ducts
near the outer edge of a classic liver lobule
. Histologically, the cells of the ductule are described as simple cuboidal epithelium
, lined partially by cholangiocytes
. They may not be readily visible but can be differentially stained
by cytokeratins CK19 and CK7.
The Canals of Hering are destroyed early in biliary cirrhosis and may be primary sites of scarring in methotrexate toxicity
. Research have indicated the presence of intraorgan stem cells of the liver that can proliferate in disease states.
They are named for Ewald Hering