In 1940 a Vichy Air Corp unit was kept inactive at Campo dell'Oro. The liberation of Corsica began with the landing by sea in 1943 of I Corps (France) at Ajaccio in Operation Vésuve. A few months later Fighter Group GC2/7 of the Free French Air Force, a French unit of the RAF, were operational on the grass field at Campo dell'Oro with Spitfires. Heavy aircraft were unable to land and came to mishap in the soft surface.
In 1944 the American Army Air Force took over the airport and put down a hard surface of perforated metallic mats from which a squadron of P-51's flew. They defended B-24's flying from new airfields constructed on the east coast of Corsica. Campo dell'Oro was a challenge for the larger aircraft because of its relatively short runways and proximity to the mountains. Toward the end of the war the runways were paved, the foundation of the modern airport. The Americans also made a concerted effort to eradicate Malaria by infilling wetlands and spraying pesticides in coastal regions.