The C.elegans protein contains 187 amino acid residues (20 kilodaltons), the human homolog 217 amino acid residues (24 kilodaltons, gene consisting of six exons spanning 11 kb and located on chromosome 16)(Asaumi et al, 1999; ).
When ubiquinone biosyntesis is interrupted by the absence of the enzyme, cells accumulate an intermediate of ubiquinone biosynthesis, demethoxyubiquinone (DMQ).
It has been shown that mutations in the gene are associated with increased lifespan (Ewbank et al, 1997; Liu et al, 2005). Defects of the gene slow down a variety of developmental and physiological processes, including the cell cycle, embryogenesis, post-embryonic growth, rhythmic behaviors and aging (Felkai et al, 1999).
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