CDP-glucose 4,6-dehydratase encyclopedia topics

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Wikipedia

In enzymology, a CDP-glucose 4,6-dehydratase is an enzyme that catalyzes the chemical reaction

CDP-glucose

rightleftharpoons

CDP-4-dehydro-6-deoxy-D-glucose + H₂O

Hence, this enzyme has one substrate, CDP-glucose, and two products, CDP-4-dehydro-6-deoxy-D-glucose and H₂O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is CDP-glucose 4,6-hydro-lyase (CDP-4-dehydro-6-deoxy-D-glucose-forming). Other names in common use include cytidine diphosphoglucose oxidoreductase, and CDP-glucose 4,6-hydro-lyase. This enzyme participates in starch and sucrose metabolism. It employs one cofactor, NAD+.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes and .

References

Hey AE, Elbein AD "Biosynthesis of tyvelose. The purification and properties of cytidine diphosphate D-glucose oxidoreductase". J. Biol. Chem. 241 5473–8.
Matsuhashi S, Matsuhashi M, Brown JG, Strominger JL "Enzymatic synthesis of cytidine diphosphate 3,6-dideoxyhexoses. 3 Cytidine diphosphate D-glucose oxidoreductase". J. Biol. Chem. 241 4283–7.
Melo A, Elliott WH, Glaser L "The mechanism of 6-deoxyhexose synthesis. I. Intramolecular hydrogen transfer catalyzed by deoxythymidine diphosphate D-glucose oxidoreductase". J. Biol. Chem. 243 1467–74.