CDP-4-dehydro-3,6-dideoxy-D-glucose + NAD(P)+ + H₂O $rightleftharpoons$ CDP-4-dehydro-6-deoxy-D-glucose + NAD(P)H + H⁺

The 4 substrates of this enzyme are CDP-4-dehydro-3,6-dideoxy-D-glucose, NAD⁺, NADP⁺, and H₂O, whereas its 4 products are CDP-4-dehydro-6-deoxy-D-glucose, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on CH or CH2 group with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is CDP-4-dehydro-3,6-dideoxy-D-glucose:NAD(P)+ 3-oxidoreductase. Other names in common use include CDP-4-keto-6-deoxyglucose reductase, cytidine diphospho-4-keto-6-deoxy-D-glucose reductase, cytidine diphosphate 4-keto-6-deoxy-D-glucose-3-dehydrogenase, CDP-4-keto-deoxy-glucose reductase, CDP-4-keto-6-deoxy-D-glucose-3-dehydrogenase system, and NAD(P)H:CDP-4-keto-6-deoxy-D-glucose oxidoreductase. This enzyme participates in starch and sucrose metabolism.

References

• Pape H, Strominger JL "Enzymatic synthesis of cytidine diphosphate 3,6-dideoxyhexoses. V Partial purification of the two protein components required for introduction of the 3-deoxy group". J. Biol. Chem. 244 3598–604.
• Rubenstein PA, Strominger JL "Enzymatic synthesis of cytidine diphosphate 3,6-dideoxyhexoses. 8 Mechanistic roles of enzyme E-1 and pyridoxamine 5'-phosphate in the formation of cytidine diphosphate-4-keto-3,6-dideoxy-D-glucose from cytidine diphosphate-4-keto-6-deoxy-D-glucose". J. Biol. Chem. 249 3776–81.
• Liu HW, Thorson JS "Pathways and mechanisms in the biogenesis of novel deoxysugars by bacteria". Annu. Rev. Microbiol. 48 223–56.

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes