Nightfall was the brainchild of producer Bill Howell, who was best known at the time for his work on CBC Playhouse and the cult favorite adventure series, Johnny Chase: Secret Agent of Space. (Howell later went on to be executive producer of CBC Radio's highly-popular series, The Mystery Project, which ran from 1992 to 2004.) When CBC Radio was revamped and given an expanded budget in 1980, Howell approached the newly-appointed Head of Radio Drama, Susan Rubes, about his idea for a supernatural/horror anthology series that would push the envelope. Though not a fan of the horror genre, Rubes recognized a hit when she saw one and gave Howell the green light to begin production.
Bill Howell served as Executive Producer of Nightfall at CBC Toronto for the first two seasons. The reins were passed for the third season to veteran CBC Radio producer Don Kowalchuk (Doctor Bundolo's Pandemonium Medicine Show) at CBC Vancouver.
Nightfall featured two hosts during its run. The Toronto years (1980–1982) were hosted by "the mysterious Luther Kranst", a character created by Bill Howell's devious imagination and played by character actor Henry Ramer. For its Vancouver run (1982–1983), Don Kowalchuk worked with voice actor Bill Reiter to develop the character of Frederick Hende.
Though series production was controlled from a central location, the anthology nature of Nightfall made it possible for episodes to be produced at CBC Radio facilities all over Canada:
| # | Title | Written by | Air Date | |||
| 1 | Love and the Lonely One | John Graham | July 4, 1980 | |||
| 2 | The Monkey's Paw | Len Peterson | July 11, 1980 | |||
| 3 | Welcome to Homerville | Don Dickinson, Allan Guttman | July 18, 1980 | |||
| 4 | Hands Off | John Graham | July 25, 1980 | |||
| 5 | The Telltale Heart | Len Peterson | Aug. 1, 1980 | |||
| 6 | Late Special | Clint Bomphray | Aug. 8, 1980 | |||
| 7 | Future Fear | John Graham | Aug. 15, 1980 | |||
| 8 | How Did You Get My Name? | Don Dickinson, Allan Guttman | Aug. 22, 1980 | |||
| 9 | The Body Snatchers | Frank W. McEnaney | Aug. 29, 1980 | |||
| 10 | The Willoughby Obsession | George R. Robertson | Sept. 5, 1980 | |||
| 11 | No Admittance/No Exit | Don Bailey, Milo Ringham | Sept. 12, 1980 | |||
| 12 | Wind Chill | David McCaughna | Sept. 19, 1980 | |||
| 13 | The Repossession | Arthur Samuels | Sept. 26, 1980 | |||
| 14 | The Stone Ship | Len Peterson | Oct. 3, 1980 | |||
| 15 | Special Services | Martin Kinch | Oct. 10, 1980 | |||
| 16 | Buried Alive | John Graham | Oct. 17, 1980 | |||
| 17 | Last Visit | Ray Will | Oct. 24, 1980 | |||
| 18 | Ringing the Changes | P. Norman Cherrie | Oct. 31, 1980 | |||
| 19 | The Devil's Backbone | Silver Donald Cameron | Nov. 7, 1980 | |||
| 20 | The Blood Countess, Part 1: Blood Red | Ray Canale | Nov. 14, 1980 | |||
| 21 | The Blood Countess, Part 2: Blood Blue | Ray Canale | Nov. 21, 1980 | |||
| 22 | Deadly Developments | Arlene Ezrin | Nov. 28, 1980 | |||
| 23 | Where Does the News Come From? | James D. (Jimmy) Morris | Dec. 5, 1980 | |||
| 24 | Where Do We Go From Here? | Max Ferguson | Dec. 12, 1980 | |||
| 25 | On Christmas Day in the Morning | Don Dickinson, Allan Guttman | Dec. 19, 1980 | |||
| 26 | The Appetite of Mr. Lucraft | P. Norman Cherrie | Dec. 26, 1980 | |||
| 27 | The Guest of Honour | Len Peterson | Jan. 2, 1981 | |||
| 28 | A Short Wave Good-bye | George R. Robertson | Jan. 9, 1981 | |||
| 29 | They Bite | Len Peterson | Jan. 16, 1981 | |||
| 30 | Dark Side of the Mind | Max Ferguson | Jan. 23, 1981 | |||
| 31 | Wildcats | Otto Lowy | Feb. 27, 1981 | |||
| 32 | The Room | Graham Haley | Mar. 6, 1981 | |||
| 33 | Angel's Kiss | John Graham, George R. Robertson | Mar. 20, 1981 | |||
| 34 | The Book of Hell | Mavor Moore | Mar. 27, 1981 | |||
| 35 | Mkara | Graham Haley | Apr. 3, 1981 | |||
| 36 | The Fatal Eggs | Arthur Samuels | Apr. 17, 1981 | |||
| 37 | Breaking Point | Max Ferguson | May 1, 1981 | |||
| 38 | All-Nighter | Graham Pomeroy | May 15, 1981 |
| # | Title | Written by | Air Date | |||
| 39 | Carmilla | John Douglas, Graham Pomeroy | Nov. 20, 1981 | |||
| 40 | In the Eye of the Beholder | Burke Campbell | Nov. 27, 1981 | |||
| 41 | Cemetery Stop | Margery Stewart | Dec. 4, 1981 | |||
| 42 | In the Name of the Father | Janet Bonellie | Dec. 11, 1981 | |||
| 43 | Baby Doll | Larry LeClair | Dec. 18, 1981 | |||
| 44 | Reunion at the Victory Café | Tom MacDonnell | Jan. 1, 1982 | |||
| 45 | Gerald | Bill Gray | Jan. 8, 1982 | |||
| 46 | Mindrift | F. Peter Lee | Jan. 15, 1982 | |||
| 47 | Your Fortune in Twenty Words or Less | Larry LeClair | Jan. 22, 1982 | |||
| 48 | Teddy | Stephen Freygood | Jan. 29, 1982 | |||
| 49 | Child's Play | Arthur Samuels | Feb. 5, 1982 | |||
| 50 | The Club of Dead Men | John Douglas | Feb. 12, 1982 | |||
| 51 | The Thinking Room | Tim Wynne-Jones | Feb. 19, 1982 | |||
| 52 | The Porch Light | Randy Brown | Feb. 26, 1982 | |||
| 53 | Volcano | Roy (T. E.) Sallows | Mar. 5, 1982 | |||
| 54 | The Monkey's Raincoat | Charles Tidler | Mar. 12, 1982 | |||
| 55 | From My Appointed Place Below | John Douglas | Mar. 19, 1982 | |||
| 56 | The Old Post Road | William Lane | Mar. 26, 1982 | |||
| 57 | The Debt | John Richard Wright | Apr. 2, 1982 | |||
| 58 | Harris and the Mare | John Douglas | Apr. 9, 1982 | |||
| 59 | The Jogger | Tony Bell | Apr. 16, 1982 | |||
| 60 | The Screaming Skull | Guy Babineau | Apr. 23, 1982 | |||
| 61 | Mr. Agostino | Janet Bonellie | Apr. 30, 1982 | |||
| 62 | The Road Ends at the Sea | Tim Wynne-Jones | May 7, 1982 | |||
| 63 | The Maid's Bell | John Douglas | May 14, 1982 | |||
| 64 | A Glimpse of Eternity | Ian Weir | May 28, 1982 | |||
| 65 | Beyond the Law | Steve Petch | June 4, 1982 | |||
| 66 | The Turn of the Blood | Paul Bettis | June 11, 1982 | |||
| 67 | Reverse Image | Arthur Samuels | June 18, 1982 | |||
| 68 | Teig O'Kane and the Corpse | John Douglas | June 25, 1982 |
| # | Title | Written by | Air Date | |||
| 69 | This One Will Kill You | Arthur Samuels | Oct. 1, 1982 | |||
| 70 | Footsteps | Larry LeClair | Oct. 8, 1982 | |||
| 71 | Lifeline | Frank Moher | Oct. 15, 1982 | |||
| 72 | The Tie That Binds | Nika Rylski | Oct. 22, 1982 | |||
| 73 | The Dentist | Bill Gray | Oct. 29, 1982 | |||
| 74 | Assassin Game | John G. Fisher | Nov. 5, 1982 | |||
| 75 | Lazarus Rising | John Douglas | Nov. 12, 1982 | |||
| 76 | Young Goodman Brown | John Douglas | Nov. 19, 1982 | |||
| 77 | But, Oh, What Happened to Hutchings! | Roy (T. E.) Sallows | Nov. 26, 1982 | |||
| 78 | Daddy's Girl | Janet Bonellie | Dec. 3, 1982 | |||
| 79 | The Cruel Husband | David Leicester | Dec. 10, 1982 | |||
| 80 | The Signalman | Otto Lowy | Dec. 17, 1982 | |||
| 81 | Watching | Bryan Wade | Dec. 31, 1982 | |||
| 82 | The Strange Odyssey of Lennis Freed | Tim Wynne-Jones | Jan. 7, 1983 | |||
| 83 | Weather Station Four | Arthur Samuels | Jan. 14, 1983 | |||
| 84 | The Brides of Olivera | Larry Gaynor | Jan. 21, 1983 | |||
| 85 | The Contract | John Richard Wright | Jan. 28, 1983 | |||
| 86 | Beauty's Beast | Burke Campbell | Feb. 4, 1983 | |||
| 87 | The Angel of Death | Raymond Storey | Feb. 11, 1983 | |||
| 88 | Semi-Detached | Shawn Selway | Feb. 18, 1983 | |||
| 89 | A Glaze of Perfect Beauty | Stephen Freygood | Feb. 25, 1983 | |||
| 90 | No Quarter | Phil Savath | Mar. 4, 1983 | |||
| 91 | The Undertaker | John Douglas | Mar. 11, 1983 | |||
| 92 | Private Collection | Warren Graves | Mar. 18, 1983 | |||
| 93 | The Hit | Laurence Gough | Mar. 25, 1983 | |||
| 94 | Walter's Dog | Larry LeClair | Apr. 1, 1983 | |||
| 95 | Safe in the Arms of Jesus | Martin Kinch | Apr. 8, 1983 | |||
| 96 | The Wedding | Phil Savath | Apr. 15, 1983 | |||
| 97 | Hypnotized | Jesse Bodyan | Apr. 22, 1983 | |||
| 98 | After Sunset | Brian Taylor | Apr. 29, 1983 | |||
| 99 | Servants of Cerberus | Mary Humphrey Baldridge | May 6, 1983 | |||
| 100 | Waters Under the Bridge | Gaëtan Charlebois | May 13, 1983 |