c-raf is gene that codes for a protein kinase. That protein is sometimes called c-Raf and will be called "Raf-1" here. The Raf-1 protein functions in the MAPK/ERK signal transduction pathway as part of a protein kinase cascade. Raf-1 is a serine/threonine-specific kinase ().
The first raf gene that was found was the oncogene v-raf. Normal (non-oncogenic) cellular homologs of v-raf were soon found to be conserved components of eukaryotic genomes and it was shown that they could mutate and become oncogenes. A-Raf and B-Raf are two protein kinases with similar sequences to Raf-1. Mutations in B-Raf genes are found in several types of cancer. The Raf kinases are targets for anticancer drug development.
Binding of 14-3-3ζ to phosphorylated serine-259 of Raf-1 is associated with inhibition of Raf-1 kinase activity. As shown in the figure (to the right), it is thought that a 14-3-3 dimer can bind to two phosphoserines of Raf-1 when it is inactive. Dephosphorylation of serine-259 has been associated with activation of Raf-1. In the model shown, the binding of GTP to Ras and the dephosphorylation of serine-259 of Raf-1 allows Raf-1 to take on a conformation that allows binding of Raf-1 to Ras-GTP. This represents a conformation in which Raf-1 can phosphorylate the downstream target MEK.
WIPO ASSIGNS PATENT TO ICO THERAPEUTICS FOR "DOSING REGIMENS FOR TREATING AND PREVENTING OCULAR DISORDERS USING C-RAF ANTISENSE" (CANADIAN INVENTORS)
Aug 12, 2011; GENEVA, Aug. 12 -- Publication No. WO/2011/097407 was published on Aug. 11. Title of the invention: "DOSING REGIMENS FOR TREATING...
WIPO ASSIGNS PATENT TO ICO THERAPEUTICS FOR "TREATING AND PREVENTING HEPATITIS C VIRUS INFECTION USING C-RAF KINASE ANTISENSE OLIGONUCLEOTIDES" (CANADIAN INVENTOR)
Sep 16, 2011; GENEVA, Sept. 16 -- Publication No. WO/2011/112516 was published on Sept. 15. Title of the invention: "TREATING AND PREVENTING...