c-Jun is the name of a gene and protein which, in combination with c-Fos, forms the AP-1 early response transcription factor. It is activated through double phosphorylation by the JNK pathway but has also a phosphorylation-independent function. c-Jun knockout is lethal, but transgenic animals with a mutated c-Jun that cannot be phosphorylated (termed c-JunAA) can survive.

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Further reading

See also

• C-Jun N-terminal kinases

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