Guthrie is currently the Republican candidate for the United States House of Representatives in Kentucky's 2nd congressional district. His opponent is Democratic State Senator David Boswell from Sorgho, Kentucky.
Guthrie earned his Bachelor's of Science in Mathematical economics from the U.S. Military Academy at West Point in 1987 and his Master's of Public and Private Management from Yale University in 1997.
Guthrie is Vice President of Trace Die Cast, Inc. an automotive parts supplier based in Bowling Green, Kentucky. Guthrie has previously served as a Field Artillery officer in the 101st Airborne Division at Fort Campbell, Kentucky.