Blood volume (BV) can be calculated given the hematocrit (HC; the fraction of blood that is red blood cells) and plasma volume (PV):
Diagnostic technologies are commercially available to measure human blood volume. A recent radionucleotide study called BVA-100, Blood Volume Analysis is the only FDA approved instrument that provides a measure of Red Blood Cells and Plasma with 98% accuracy.
Blood volume measurement is indicated for the diagnosis and treatment patients suffering from Congestive Heart Failure, Chronic Hypertension, Renal Failure and Critical Care.