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Bile acid sequestrant

Bile-acid-CoA hydrolase

In enzymology, a bile-acid-CoA hydrolase is an enzyme that catalyzes the chemical reaction

deoxycholoyl-CoA + H2O rightleftharpoons CoA + deoxycholate

Thus, the two substrates of this enzyme are deoxycholoyl-CoA and H2O, whereas its two products are CoA and deoxycholate.

This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name of this enzyme class is deoxycholoyl-CoA hydrolase.

References

  • Ye HQ, Mallonee DH, Wells JE, Bjorkhem I, Hylemon PB "The bile acid-inducible baiF gene from Eubacterium sp. strain VPI 12708 encodes a bile acid-coenzyme A hydrolase". J. Lipid. Res. 40 17–23.

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