Sakmann, Bert, 1942-, German biophysicist, M.D. Univ. of Göttingen, Germany, 1974. He has been a researcher at the Max Planck Institute for Biophysical Chemistry in Göttingen since 1974. Sakmann received the 1991 Nobel Prize in physiology or medicine with Edwin Neher for their joint discoveries concerning the functioning of ion channels in cell membranes. Neher and Sakmann are credited with establishing the existence and describing the functioning of ion channels and with developing the patch-clamp technique, a method of measuring the tiny electrical currents produced as the ions pass through the channels. Their work brought about a revolution in the field of cell biology, providing a new approach for the study of disease mechanisms and the development of drug treatments.

Bert Sakmann (born June 12, 1942) is a German cell physiologist. He shared the Nobel Prize in Physiology or Medicine with Erwin Neher in 1991 for their work on "the function of single ion channels in cells," and invention of the patch clamp. Bert Sakmann was Professor at Heidelberg University and is an Emeritus Scientific Member of the Max Planck Institute for Medical Research in Heidelberg, Germany. Since 2008 he leads an emeritus research group at the Max Planck Institute of Neurobiology.

Born in Stuttgart, Sakmann enrolled in Volksschule in Lindau, and completed the Wagenburg gymnasium in Stuttgart in 1961. He studied medicine from 1967 onwards in Tübingen, Freiburg, Berlin, Paris and Munich. After completing his medical exams at Ludwig-Maximilians University in Munich, he became a medical assistant in 1968 at Munich University, while also working as a scientific assistant (Wissenschaftlicher Assistant) at Munich's Max-Planck-Institut für Psychiatrie, in the Neurophysiology Department under Otto Detlev Creutzfeldt. In 1971 he moved to University College London, where he worked in the Department of Biophysics under Bernard Katz. In 1974 he completed his medical dissertation, under the title Elektrophysiologie der neuralen Helladaptation in der Katzenretina (Electrophysiology of Neural Light Adaption in the Cat Retina) in the Medical Faculty of Göttingen University.

Afterwards (still in 1974), Sakmann returned to the lab of Otto Creutzfeldt, who had meanwhile moved to the Max Planck Institute for Biophysical Chemistry in Göttingen. Sakmann joined the membrane biology group the in 1979.

In 1986, he was awarded the Louisa Gross Horwitz Prize from Columbia University together with Erwin Neher co-winner of 1991 Nobel prize for Physiology or Medicine.

In 1987, he received the Gottfried Wilhelm Leibniz Prize of the Deutsche Forschungsgemeinschaft, which is the highest honour awarded in German research.

In 1991 he received the Nobel prize for Physiology or Medicine together with Neher, with whom he had worked in Göttingen.

Sakmann is the founder of the Bert-Sakmann-Stiftung.

References

Bibliography

• WJ Betz & B Sakmann (1971). ""Disjunction" of frog neuromuscular synapses by treatment with proteolytic enzymes". Nature New Biol. 232 94–95.
• WJ Betz & B Sakmann (1973). "Effects of proteolytic enzymes on synaptic structure and function". J. Physiol. 230 673–688.

External links

• Nobel autobiography
• The Official Site of Louisa Gross Horwitz Prize