He also founded (in 1833) and edited the American Quarterly Observer; from 1836 to 1841 edited the Biblical Repository (after 1837 called the American Biblical Repository) with which the Observer was merged in 1835; and was editor-in-chief of Bibliotheca Sacra from 1844 to 1851. In 1837 he became professor of Hebrew at Andover, and from 1848 until his death was associate professor of sacred literature there. He was a founder of the Society for Ameliorating the Condition of the Slave and of the American Missionary Society. He died at Athens, Georgia, on 20 April 1852.
Among his numerous publications were The Missionary Gazetteer (1832); The Biography of Self-Taught Men, with an Introductory Essay (1832); Memoir of Reverend Elias Cornelius (1833); a once widely known Eclectic Reader (1830s); a translation, with Samuel Harvey Taylor (1807-1871), of Kuhner's Schulgrammatik der Griechischen Sprache and Classical Studies (1844), essays in ancient literature and art written in collaboration with Barnas Sears and C. C. Felton.
Edward's Addresses and Sermons, with a memoir by Rev. Edwards A. Park (1808-1900), were published in two volumes at Boston in 1853.