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When hunting with a rifle, a higher BC is desirable for several reasons. A higher BC results in a flatter trajectory which in turn reduces the effect of errors in estimating the distance to the target. This is particularly important when attempting a clean hit on the vitals of a game animal. If the target animal is closer than estimated, then the bullet will hit higher than expected. Conversely, if the animal is further than estimated the bullet will hit lower than expected. Such a difference in bullet drop can often make the difference between a clean kill and a wounded animal.
This difference in trajectories becomes even more critical at longer ranges. For some cartridges, the difference in two bullet designs fired from the same rifle can result in a difference between the two of over 30 cm (1 foot) at 500 meters (550 yards). The difference in impact energy can also be great because kinetic energy depends on the square of the velocity. A bullet with a high BC arrives at the target faster and with more energy than one with a low BC.
Since the higher BC bullet gets to the target faster, it is also less affected by the crosswinds.
Ammunition makers often offer several bullet weights and types for a given cartridge. Heavy-for-caliber pointed (spitzer) bullets with a boattail design have the high BC's, whereas lighter bullets with square tails and blunt noses have lower BCs. The 6 mm and 6.5 mm cartridges are probably the most well known for having high BC bullets and are often used in long range target matches of 300-1000 meters. The 6 and 6.5 have relatively light recoil compared to larger calibers with high BC bullets and tend to take matches where accuracy is key. Examples include the 6mm PPC, 6 mm BR Norma, 6 x 47 SM, 6.5 Grendel and the 6.5-284. The 6.5 mm is also a very popular hunting caliber in Europe.
In the United States, hunting cartridges such as the .25-06 Remington (a 6.35 mm caliber), the .270 Winchester (a 6.8 mm caliber), and the 7 mm-08 Remington (a .284" caliber) are used when high BCs and moderate recoil are desired. The .30-06 Springfield and .308 Winchester cartridges also offer several high-BC loads, although the bullet weights are on the heavy side. The .308 is also a favorite long-range target cartridge.
In the larger caliber category, the .338 Lapua Magnum and the .50 BMG are popular with very high BC bullets for shooting beyond 1000 meters. New competitors in the larger caliber category are the .375 and .408 Cheyenne Tactical and the .416 Barrett.
For the precise establishment of BCs (or perhaps the scientifically better expressed drag coefficients), Doppler radar-measurements are required. The normal shooting or aerodynamics enthusiast, however, has no access to such expensive professional measurement devices. Weibel 1000e Doppler radars are used by governments, professional ballisticians, defense forces, and a few ammunition manufacturers to obtain exact real world data on the flight behavior of projectiles of interest.
The ballistic coefficient of an atmospheric reentry vehicle has a significant effect on its behavior. A very high ballistic coefficient vehicle would lose velocity very slowly and would impact the Earth's surface ("auger in") at supersonic speeds. In contrast, a low ballistic coefficient vehicle would decelerate more rapidly and would thus experience less heating from atmospheric friction. In general, reentry vehicles that carry human beings back to Earth from space have high drag and a correspondingly low ballistic coefficient. Vehicles that carry nuclear weapons launched by an Intercontinental Ballistic Missile (ICBM), by contrast, have a high ballistic coefficient, which enables them to travel rapidly from space to a target on land. That makes the weapon less affected by crosswinds or other weather phenomena, and harder to track, intercept, or otherwise defend against.