He came from a wealthy family that had many notable figures. His father, Benizelo Roufus, was a wealthy Sicilian who held an administrative post in Calabria. His son was also called Benizelos Rouphos who also served as Prime Minister of Greece later on. Other members of the family served as mayors, members of parliament and ministers. He married Paraskevi Kostaki and apart from the aforementioned son they had a daughter called Aggeliki.