• Alicia O'Shea Petersen, Tasmanian suffragist
• Brian O'Shea (politician), Irish politician
• Brian O'Shea (boxer), American boxer
• Brian O'Shea (GAA Referee) ,
• Clarrie O'Shea, Australian labor union secretary.
• Dylan O'Shea, secretary of Commerce in Irish Municipal Parliament.
• Franc O'Shea, bass guitar player and composer.
• James O'Shea and John O'Shea, Victorian stone carvers associated with John Ruskin.
• John O'Shea, Irish football player.
• John O'Shea, New Zealand film director.
• John O'Shea, founder of GOAL, international humanitarian organization based in Ireland.
• Katherine O'Shea, aka Kitty O'Shea, wife of Irish politician, Charles Stewart Parnell.
• Kelvin O'Shea, Australian rugby league footballer
• Mark O'Shea, English herpetologist.
• Mike O'Shea, Canadian football player.
• Mike O'Shea, All american Quarterback of the Bishop Shanahan Eagles (05-08)
• Milo O'Shea, Irish actor.
• Patrick O'Shea, American composer and conductor.
• Rick O'Shea, Irish radio DJ.
• Steve O'Shea, cephalopod systematicist and biogeographer
• Tessie O'Shea, Welsh entertainer and actress
• Timothy O'Shea, vice-chancellor and principal of the University of Edinburgh.
• William O'Shea

Much less commonly, O'Shea might be used as a first name:

• O'Shea Jackson, the rapper commonly known as Ice Cube

See also

• O'Shea and Whelan
• Shea (disambiguation)