San Pablo City National High School(Filipino: Pambansang Mataas na Paaralan ng Lungsod ng San Pablo) is one of the 12 functioning public secondary schools of San Pablo City. Located in F. Mariño St., Lakeside Park Subdivision, Brgy. VI-D, San Pablo City, it provides free secondary education for the people of the city and neighboring towns with a science curriculum. Abbreviated as SPCNHS, students nicknamed it "City High" or "City High Main".
|Subject||First Year||Second Year||Third Year||Fourth Year|
|English||Grammar 1||Grammar 2||Afro-American Literature||World Literature|
|Mathematics||Elementary Algebra||Intermediate Algebra||Geometry||Advanced Algebra, Trigonometry & Statistics|
|Science & Technology||General Science||Biology||Chemistry||Physics|
|Filipino||Balarila/Ibong Adarna||Teksto/Florante at Laura||Panitikang Pilipino/Noli Me Tangere||Panitikang Asyano/El Filibusterismo|
|Araling Panlipunan||Kasaysayan at Pamahalaan ng Pilipinas||Araling Asyano||Kasaysayan ng Daigdig||Ekonomiks|
|MAPEH (Music, Arts, Physical Education and Health)||MAPEH 1||MAPEH 2||MAPEH 3||MAPEH 4/CAT(Citizenship Advancement Training)|
|TLE (Technology & Livelihood Education)¹||optional||optional||optional||optional|
¹SPCNHS offers the following TLE courses: Cosmetology, Agriculture, Computer, Home Economics and Electricity.
SPCNHS has 91 teachers as of March 29, 2007. They are grouped into seven departments each is headed by a department head. There are eleven teachers under English, 15 under Mathematics, 16 under Science and Technology, 13 under Filipino, 13 under Araling Panlipunan, 10 under MAPEH, and 13 under T.L.E. In addition, 11 serve as administrative staff. All of these is headed by a secondary school principal.