Apis, in Egyptian religion, sacred bull of Memphis, said to be the incarnation of Osiris or of Ptah. His worship spread throughout the Mediterranean world and was particularly important during the time of the Roman Empire. See also Serapis.

In ancient Egyptian religion, a sacred bull deity worshiped at Memphis. The cult originated at least as early as the 1st dynasty (circa 2925–circa 2775 BCE). Apis was probably at first a fertility god but became associated with Ptah and also with Osiris and Sokaris, gods of the dead. When an Apis bull died, it was buried with great pomp, and the calf that was to be its successor was installed at Memphis. Apis's priests drew omens from the bull's behaviour, and his oracle had a wide reputation. The worship of Serapis (a combination of Osiris and Apis) probably arose at Memphis in the 3rd century BCE and became one of the most widespread Eastern cults in the Roman Empire.

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Apis may refer to:

• Apis (Egyptian mythology), an Egyptian god
• Apis (city), an Egyptian city
• Yamu, another Egyptian city, formerly called Apis
• Apis (genus), the genus of honeybees
• Apis (Greek mythology), a prophet in Greek mythology
• Apis (constellation), an obsolete constellation
• Apis, the nickname of Dragutin Dimitrijević of the Serbian Black Hand
• Apis (One Piece), a fictional character in the Warship Island arc of the anime One Piece
• Apis, an ultralight glider
• Advance Passenger Information System, a border control mechanism used by the United States, Korea, and other countries.