For example, for the Roman patron, Massimo Massimi, he painted an Ecce Homo (now in Palazzo Pitti). Supposedly unbenknownst to any of the painters, two other prominent contemporary painters, Passignano and Caravaggio, had been requested canvases on the same theme. It is unclear if they are completely independent. Cigoli's painting seems to have been made with knowledge of Caravaggio's canvas; however, while Cigoli's work lacks the power of Caravaggio's naturalism, the background shade and sparse foreground shows how much he was moving away from crowded Florentine historical paintings. This work was afterwards taken by Bonaparte to the Louvre, and was restored to Florence in 1815.
One of his early paintings was of Cain slaying Abel. He then gained the employ of the Grand-Duke in some works for the Pitti Palace, where he painted a Venus and Satyr and a Sacrifice of Isaac.
Other important pictures are St. Peter Healing the Lame Man in St Peter's; Conversion of St. Paul in the church of San Paolo fuori le Mura, and a Story of Psyche in a fresco incorporated in the decorative scheme of the Villa Borghese; a Martyrdom of Stephen, which earned him the name of the "Florentine Correggio", a Stigmata of St. Francis at Florence. Cigoli was made a Knight of Malta at the request of Pope Paul III.
He painted a last fresco in the dome of the Roman church of Santa Maria Maggiore. His pupils include Cristofano Allori (1577-1621), the Fleming Giovanni Biliverti (1576-1644), Domenico Fetti, Giovanni Antonio Lelli, Aurelio Lomi, Pietro Medici, Gregorio Pagani, and Andrea Comodi (1560-1638).