The game pieces consist of a set of tiles with letters on them. Tiles are turned over one by one, and players form words by combining unused tiles with existing words, their own or others'. The game has never been standardized and there exist a great many varieties of sets and rules. Anagrams is now often played with tiles from another word game, such as Scrabble.
In 1975, Selchow published the Scrabble Scoring Anagrams version which featured tiles with point values similar to the familiar Scrabble system. Another version was published in the 1960s by the now defunct Transogram. The Embossing Company also produced a yellow-on-black Eye-Rest set. Many other versions have been produced and used sets can still be found on internet auction and specialty sites. A variation called Up For Grabs was published by Tyco in 1995. Portobello Games produces it under the name Snatch.
Prodijeux has been marketing a variant called wordXchange since 2000
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Many players use several Scrabble or Upwords sets together.A version of the game seems to be popular among tournament Scrabble players. Writers John Ciardi, James Merrill, John Malcolm Brinnin, and Richard Wilbur reputedly played together regularly in Key West, Florida, with novelist John Hersey also sometimes sitting in.
There has never been a standardized set of rules, and players now often play by house rules, but most are variants of the rules given here.
To begin, all the tiles are placed face down in the middle of the table. Taking turns around the table, each player turns over one tile, placing it in clear view of all players.
Another variation is to have each player have a "bank" of tiles in front of themselves, which affords players a clearer view of the "pool" of face-up letter tiles in the middle of the table.
Whenever a player can form a word with the tiles in the middle of the table, possibly combined with words that he or another player has already formed, he calls out the word and uses those tiles to spell it out in front of him. If two players call out words simultaneously, the longer word prevails. If two players call out the SAME word simultaneously, those two players each turn a new tile face up, and the player whose letter is closest to "A" wins the word (the "tie-breaker" tiles are flipped back over and remixed with the other face-down tiles).
All words must be at least four letters long, or three in some rules. Tournament Scrabble players often play with a minimum word length of six or seven.
The minimum acceptable word length can be adjusted to a player's skill level (for example, in a game with adults and children playing together, the children may be permitted to form four-letter words, while the adults are restricted to words of at least five or six letters).
New words cannot be mere plurals of existing words; some rules require that the new word change the root of the old, thus allowing APPEAR to become PARAPET (+T), but not APPEARED (+E+D) or REAPPEAR (+E+R). A player may modify his own words, subject to the same rule.
Some versions only allow players to make or steal words on their turn (this slows down play).
The game ends when all tiles are face-up and no one can create or steal any more words.
There are various scoring systems:
| A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z |
| 13 | 5 | 6 | 7 | 24 | 6 | 7 | 6 | 12 | 2 | 2 | 8 | 8 | 11 | 15 | 4 | 2 | 12 | 10 | 10 | 6 | 2 | 4 | 2 | 2 | 2 |
A variant with 220 letters:
| A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z |
| 14 | 6 | 6 | 8 | 20 | 6 | 8 | 10 | 14 | 4 | 4 | 8 | 8 | 12 | 14 | 6 | 4 | 12 | 12 | 14 | 10 | 4 | 8 | 2 | 4 | 2 |
The distribution of 180 letters for Scrabble Scoring Anagrams (according to a review on funagain.com):
| A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z |
| 16 | 4 | 4 | 8 | 22 | 4 | 6 | 6 | 14 | 2 | 2 | 8 | 4 | 10 | 14 | 4 | 2 | 12 | 8 | 10 | 8 | 2 | 2 | 2 | 4 | 2 |